Title 49 of the US Code of Federal Regulations (49 CFR) contains all US regulations dealing with transportation into, out of, and within the United States. The Title has nine volumes, and various components of the Departments of Transportation and Homeland Security author the regulations it contains. Most notably, 49 CFR contains the US Hazardous Material Regulations (HMR) in Parts 100-185. The new 2008 editions of all CFR titles have red covers.

Changes to 49 CFR since the last edition year, aside from non-substantive housekeeping changes, include the following:

• Gasoline/Ethanol Fuel Blends now appear in the Hazmat table. UN 1203 and UN 1987 proper shipping name variants were added to better describe these mixtures, and UN 3475 was created. (49 CFR, Parts 171 and 172)
• Shipping Papers now must declare marine pollutants in non-bulk packaging if any or all of the transportation is by vessel. Previously, shippers preparing documentation for these shipments had no obligation to declare the marine pollutants if the initial transport was by road or rail. This would usually lead to a freight forwarder improperly describing the shipment when passing it along to a vessel carrier. (49 CFR, Parts 171 and 172)